Nocturia Improves with Antidiuretic

By Charles Bankhead, Staff Writer, MedPage TodayPublished: June 07, 2010 Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner SAN FRANCISCO -- Nocturnal polyuria and its associated adverse effects declined quickly and significantly during treatment with a quick-dissolving oral formulation of desmopressin, investigators in a multicenter clinical trial reported here. The frequency of nocturnal voiding declined by as much as 50%, and the voided volume of nocturnal urine decreased by as much as 40%. The initial period of uninterrupted sleep doubled or tripled across the range of desmopressin doses, as compared with placebo.